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T-705 ribosyl triphosphate – CAS 740790-94-7

T-705 ribosyl triphosphate – CAS 740790-94-7 is synthesized by SigutLabs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

T-705 ribosyl triphosphate triethyl ammonium or sodium salt

This compound is for research use only. We do not sell to patients.

Amount

5 mg	€ 5000	Stock
25 mg	€ 7000	Stock
Do you want custom amount?			Custom amount

Amount

5 mg

€ 5000

Stock

25 mg

€ 7000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 740790-94-7

IUPAC name: [[(2R,3S,4R,5R)-5-(3-carbamoyl-5-fluoro-2-oxopyrazin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Other names: Favipiravir-rtp; T-705RTP; Favipiravir riboside triphosphate;

Molecular weight: 529.16 g/mol (free acid)

Molecular formula: C₁₀H₁₅FN₃O₁₅P₃

InChI: InChI=1S/C10H15FN3O15P3/c11-4-1-14(9(18)5(13-4)8(12)17)10-7(16)6(15)3(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h1,3,6-7,10,15-16H,2H2,(H2,12,17)(H,22,23)(H,24,25)(H2,19,20,21)/t3-,6-,7-,10-/m1/s1

Description

T-705-RTP is the active triphosphate metabolite of favipiravir (T-705) and a selective, GTP-competitive inhibitor of influenza virus RNA-dependent RNA polymerase (RdRp), with an IC50 of 0.14 μM. Once favipiravir is incorporated into cells, it undergoes intracellular phosphoribosylation to form T-705-RTP, which is then recognized as a substrate by RdRp, ultimately inhibiting viral RNA polymerase activity.

T-705-RTP is incorporated into the nascent RNA chain, inducing chain termination or lethal mutagenesis. Biochemical studies confirm that T-705-RTP acts like purines or purine nucleosides in human cells and does not inhibit human DNA synthesis, underpinning its selectivity for viral over host polymerases.

As the pharmacologically active end-metabolite of favipiravir, T-705-RTP is an essential reference standard for pharmacokinetic studies, RdRp inhibition assays, and intracellular drug metabolism research — including LC-MS/MS quantification in biological matrices.

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Payment

Payment terms 30 days net
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References

Huchting, J., Winkler, M., Nasser, H., & Meier, C. (2017). Synthesis of T‐705‐Ribonucleoside and T‐705‐Ribonucleotide and Studies of Chemical Stability. ChemMedChem, 12(9), 652-659.
Furuta, Y., Komeno, T., & Nakamura, T. (2017). Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proceedings of the Japan Academy, Series B, 93(7), 449-463.
Wang, G., Wan, J., Hu, Y., Wu, X., Prhavc, M., Dyatkina, N., … & Beigelman, L. (2016). Synthesis and anti-influenza activity of pyridine, pyridazine, and pyrimidine C-nucleosides as favipiravir (T-705) analogues. Journal of medicinal chemistry, 59(10), 4611-4624.