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T-705 Ribofuranose – CAS 356782-88-2

T-705 Ribofuranose – CAS 356782-88-2 is synthesized by SigutLabs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

T-705 Ribofuranose

This compound is for research use only. We do not sell to patients.

Amount

10 mg	€ 1000	Stock
50 mg	€ 2000	Stock
Do you want custom amount?			Custom amount

Amount

10 mg

€ 1000

Stock

50 mg

€ 2000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 356782-88-2

IUPAC name: 4-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-fluoro-3-oxopyrazine-2-carboxamide

Other names: T-705 Ribofuranose; Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-4-b-D-ribofuranosyl-; 6-Fluoro-3,4-dihydro-3-oxo-4-ss-D-ribofuranosyl-2-pyrazinecarboxamide

Molecular weight: 289.22 g/mol

Molecular formula: C₁₀H₁₂FN₃O₆

InChI: InChI=1S/C10H12FN3O6/c11-4-1-14(9(19)5(13-4)8(12)18)10-7(17)6(16)3(2-15)20-10/h1,3,6-7,10,15-17H,2H2,(H2,12,18)/t3-,6-,7-,10-/m1/s1

Description

T-705 Ribofuranose is a key metabolic intermediate and impurity reference standard in the favipiravir (T-705) pathway. Favipiravir is an antiviral compound that is phosphoribosylated by cellular enzymes to its active triphosphate form (favipiravir-RTP), which selectively inhibits the RNA-dependent RNA polymerase of influenza virus. T-705 Ribofuranose represents an early-stage metabolite in this activation cascade, making it a valuable analytical standard for pharmacokinetic and metabolic studies.

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Payment

Payment terms 30 days net
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References

Huchting, J., Winkler, M., Nasser, H., & Meier, C. (2017). Synthesis of T‐705‐Ribonucleoside and T‐705‐Ribonucleotide and Studies of Chemical Stability. ChemMedChem, 12(9), 652-659.
Furuta, Y., Komeno, T., & Nakamura, T. (2017). Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proceedings of the Japan Academy, Series B, 93(7), 449-463.
Wang, G., Wan, J., Hu, Y., Wu, X., Prhavc, M., Dyatkina, N., … & Beigelman, L. (2016). Synthesis and anti-influenza activity of pyridine, pyridazine, and pyrimidine C-nucleosides as favipiravir (T-705) analogues. Journal of medicinal chemistry, 59(10), 4611-4624.