ADC linkers

Power your antibody drug conjugates with bespoke linker chemistry

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Get faster access to conjugation-ready linkers

If your antibody drug development team has the idea but no synthetic lab capacity, or you’re opening a new clinical program, we bring the chemistry muscle so your biology team can test antibody drug conjugates faster.

Our team of PhD chemists delivers ADC linker design, optimized or de novo, through synthesis and purification. Matched to your payload, release mechanism, and conjugation strategy, our tailored linkers support antibody drug discovery and fit your antibody drug development process, with deliveries ready for ADC conjugation.

Made in Europe with strict IP policy and clear updates, including go/no-go checkpoints. Backed by QA documentation, CDMO-ready data, a track record of ~200 linker–payloads, and experience supporting client programs that have advanced to Phase 1.

Partner with us to save

Time

on slow design iterations

Senior chemistry

on tricky conjugation routes

IP & security

on data and IP exposure

Linker-payloads for ADCs

ENZYMATICALLY CLEAVABLE LINKERS

REBRIDGING GROUPS

MALEIMIDE HYDROLYSIS

DISULFIDE LINKERS

CYSTEINE-SELECTIVE

ANTI SELF-AGGREGATION

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Skip dead-ends
with vial-ready ADC linkers

We are seasoned in

Enzymatically cleavable linkers

Cystein-selective warheads

Clickable linkers

Rebridging groups

Disulfide linkers

Suppression of self-aggregation

pH-sensitive lakers

Self-immolative motifs

With every project, you get expert assistance on linker selection, rigorous evaluation of stability and hydrophilicity, and guidance on cleavable vs non-cleavable options and triggers. We align the payload release mechanism, antibody-attachment strategy (warhead), and DAR control with your program’s goals, and you receive CDMO-ready documentation for smooth tech transfer.

Prefer data over claims? See our ADC blog for design rationales and examples.

Don’t see your approach listed? Tell us what you need to test – we’ll build linker chemistry around it.

Move from concept to candidates

Our customers include

Start-Ups

We assist small start-ups in exploring their novel ideas, e.g., in order to obtain preliminary data for investors.

Spin-offs

We provide laboratory services to spin-offs lacking their own facilities dedicated to complex organic synthesis.

Universities

We offer budget-friendly research for universities to build on and provide unique substances that are not commercially available.

Pharma

We assist large pharmaceutical companies with synthesis so that they can focus on more difficult aspects of drug development.

Biotech

We have years of experience in organic, bioorganic, and medicinal chemistry, taking your projects to the next level.

Medical

We specialize in antiviral nucleosides and nucleotides, but we are always interested in novel and challenging syntheses.

If you haven´t found your area listed above, feel free to contact us and we will let you know how we can help. We are ready to rise to any challenge.

“Sigut Labs' ability to rapidly adapt and optimize the synthesis process was impressive. They efficiently scaled up production and delivered gram quantities within weeks. I am convinced that making pro-N6pA commercially available through Sigut Labs will significantly benefit the scientific community by simplifying access to this vital research tool.”

Dr. Pavel Kielkowski /Kielkowski Research Group/

“Our molecule is now in the preclinical phase thanks to scale up done by the SigutLabs team.”

Dr. Jiří Janata /Institute of Microbiology of the Czech Academy of Sciences/

“SigutLabs supported our research by providing custom-synthesized ddhC-derived nucleotide analogues, which were essential for our Viperin-related studies and for generating preliminary data supporting future grant applications. We greatly valued their scientific expertise, particularly their guidance in selecting the most appropriate molecular formats, as well as the speed, quality, and reliability of their custom synthesis services. All compounds were delivered promptly, at excellent purity, and were immediately suitable for use in our experimental assays.”

Assistant senior lecturer Soham Gupta /Karolinska Institutet Sweden/

“We were really surprised that such a small company was able to develop an innovative technology that enabled the purification of large quantities of our crude product. Moreover, in such a short time. Job well done!”

Ralphy Cooper /Independent Consultant/

“The compounds we received are of high quality. The accompanying information is helpful for us in designing our experiments.”

Professor Anthony Leung /Johns Hopkins University/

“Collaborating with SigutLabs on our CDK and GSK inhibitor research was a game-changer. Their expertise proved very useful in transforming our initial research concepts into a robust scientific program.”

Assoc. Professor Milan Jakubek /First Faculty of Medicine, Charles University/

How we work

Take a sneak peek into our processes

1. INQUIRY

When contacted, we typically respond within 24 hours, providing as much information as possible straight away.

2. NDA

Ensuring the confidentiality of your data is our top priority from the very first moment. Typically, we sign a non-disclosure agreement before the first client meeting where relevant.

3. KICK-OFF

After the client accepts our offer, we're prepared to assist in scaling up your process or synthesizing your desired products on a large scale. We provide custom quantities ranging from 1 mg to 10 kg of the final product. We aim to identify efficient pathways that reduce reaction steps and purifications, ultimately saving time and costs.

What questions
clients often ask

We do not perform in-house conjugation. We deliver linker and linker–payload chemistry ready for your conjugation workflow, and if needed, we can connect you with trusted partners who can support conjugation.

Yes, you can pay by card or bank transfer. New customers are asked for advance payment. We send invoices on the same day as the shipment. We also offer invoice modifications for academic institutions, facilitating payment through grants.

If you can’t find the information you need on a product sheet, feel free to reach out to us at lab@sigutlabs.com. We’ll strive to reply to you as soon as possible.

Each package is meticulously packed. For temperature-sensitive compounds, we ensure shipping on dry ice. We rely on DHL service for worldwide shipments. Typically, packages arrive within 24 hours in the EU and within 48-72 hours elsewhere (subject to customs delays) and we provide a tracking number for every package.

Yes, our products are exclusively for research and development purposes. They cannot be used or sold for treating patients, animals, etc.

Rest assured, the confidentiality of your data is our utmost priority right from the start. Typically, we sign a non-disclosure agreement before our initial meeting with a client.

If you need to make a purchase for a university and are required to get an official quote before placing the order, please contact us at lab@sigutlabs.com. We will send you an official quote within 24 hours.