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Fialuridine – CAS 69123-98-4

Fialuridine – CAS 69123-98-4 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Fialuridine

This compound is for research use only. We do not sell to patients.

Amount

1 g		€ 700	Stock
Do you want custom amount?				Custom amount

Amount

1 g

€ 700

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 69123-98-4

IUPAC name: 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

Other names: FIAU; 2′-fluoro-5-iodoarauracil

Molecular weight: 372.09 g/mol

Molecular formula: C₉H₁₀FIN₂O₅

InChI: InChI=1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1

Description

Fialuridine is a compound with potential applications in the fight against Hepatitis B virus (HBV). It might selectively inhibits the HBV polymerase, an enzyme crucial for viral replication. This targeted approach could potentially minimize side effects compared to some existing HBV treatments.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

McKenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., Di Bisceglie, A. M., Park, Y., … & Hoofnagle, J. H. (1995). Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. New England Journal of Medicine, 333(17), 1099-1105.
Lewis, W., Levine, E. S., Griniuviene, B., Tankersley, K. O., Colacino, J. M., Sommadossi, J. P., … & Perrino, F. W. (1996). Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proceedings of the National Academy of Sciences, 93(8), 3592-3597.