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Cidofovir diphosphate – CAS 142276-31-1

Cidofovir diphosphate – CAS 142276-31-1 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

Cidofovir diphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 1500	Stock
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Amount

1 mg

€ 1500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 142276-31-1, 352525-57-6 (Na+ salt), 2375137-54-3 (Et3NH+ salt)

IUPAC name: [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

Other names: CDVpp, CDV diphosphate

Molecular weight: 439.15 g/mol

Molecular formula: C₈H₁₆N₃O₁₂P₃

InChI: InChI=1S/C8H16N3O12P3/c9-7-1-2-11(8(13)10-7)3-6(4-12)21-5-24(14,15)22-26(19,20)23-25(16,17)18/h1-2,6,12H,3-5H2,(H,14,15)(H,19,20)(H2,9,10,13)(H2,16,17,18)/t6-/m0/s1

Description

Cidofovir diphosphate is a crucial active metabolite of the antiviral drug Cidofovir. It’s known for its powerful antiviral activity, particularly against:

Cytomegalovirus (CMV): Cidofovir diphosphate effectively inhibits the replication of CMV, a major threat to immunocompromised individuals.
Other Viruses: It may also show activity against various other viruses, making it a potential candidate for broader antiviral applications.

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Payment

Payment terms 30 days net
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References

Magee, W. C., Hostetler, K. Y., & Evans, D. H. (2005). Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrobial agents and chemotherapy, 49(8), 3153-3162.
Xiong, X., Smith, J. L., Kim, C., Huang, E. S., & Chen, M. S. (1996). Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase. Biochemical pharmacology, 51(11), 1563-1567.
Cundy, K. C. (1999). Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clinical pharmacokinetics, 36(2), 127-143.