Adefovir diphosphate – CAS 129532-77-0
Adefovir diphosphate – CAS 129532-77-0 is synthesized by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
min 95%
Package contents
Adefovir diphosphate triethylammonium salt
This compound is for research use only. We do not sell to patients.
Amount
| 1 mg | € 450 | Stock | ||
| 5 mg | € 800 | Stock | ||
| Do you want custom amount? | Custom amount | |||
Amount
1 mg
€ 450
Stock
5 mg
€ 800
Stock
Do you want custom amount?
Custom amount
Characterisation
CAS: 129532-77-0, 255835-57-5 (Li+ salt), 1346598-45-5 (Et3NH+ salt)
IUPAC name: 2-(6-aminopurin-9-yl)ethoxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
Other names: PMEApp, Adefovir diphosphate, PMEA-DP,
Molecular weight: 433.15 g/mol
Molecular formula: C8H14N5O10P3
InChI: InChI=1S/C8H14N5O10P3/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-21-5-24(14,15)22-26(19,20)23-25(16,17)18/h3-4H,1-2,5H2,(H,14,15)(H,19,20)(H2,9,10,11)(H2,16,17,18)
Description
Adefovir diphosphate is a metabolite of adefovir. An antiviral acyclic nucleoside phosphonate (ANP) analog known as adefovir monophosphate has activity against the herpes, hepatitis B, and human immunodeficiency viruses (HIV). For the treatment of hepatitis B, it is an oral acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that inhibits reverse transcriptase.
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References
- Shen, Y., Zhukovskaya, N. L., Zimmer, M. I., Soelaiman, S., Bergson, P., Wang, C. R., … & Tang, W. J. (2004). Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proceedings of the National Academy of Sciences, 101(9), 3242-3247.
- Gu, Z., Salomon, H., Cherrington, J. M., Mulato, A. S., Chen, M. S., Yarchoan, R., … & Wainberg, M. A. (1995). K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl) adenine. Antimicrobial agents and chemotherapy, 39(8), 1888-1891.
- Birkuš, G., Votruba, I., Holý, A., & Otová, B. (1999). 9-[2-(phosphonomethoxy) ethyl] adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε∗. Biochemical pharmacology, 58(3), 487-492.
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