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3′,4′-Didehydro-3′-deoxycytidine triphosphate – CAS 2279171-34-3

3′,4′-Didehydro-3′-deoxycytidine triphosphate – CAS 2279171-34-3 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxycytidine triphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 1000	Stock
5 mg	€ 2500	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 1000

Stock

5 mg

€ 2500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 2279171-34-3, 2657712-17-7 ( Et3NH+ salt)

IUPAC name: 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-4-Amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]-1,2-dihydropyrimidin-2-one triphosphate

Other names: 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-2(1H)-Pyrimidinone Triphosphate, DdhCTP, DdhC-TP

Molecular weight: 465.15 g/mol

Molecular formula: C₉H₁₄N₃O₁₃P₃

InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2,4,8,13H,3,5H2,1H3,(H,11,14,15)/t8-/m1/s1

Description

3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have an antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

3′,4′-didehydro-3′-deoxycytidine triphosphate is provided as triethylammonium salt.

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Payment

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References

Wang, F. (2007). Unsaturated Didehydrodeoxycytidine Drugs. 1. Impact of CC Positions in the Sugar Ring. The Journal of Physical Chemistry B, 111(32), 9628-9633.
Torrance, C. J., Agrawal, V., Vogelstein, B., & Kinzler, K. W. (2001). Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nature biotechnology, 19(10), 940-945.
Mehta, R., Chekmeneva, E., Jackson, H., Sands, C., Mills, E., Arancon, D., … & Sriskandan, S. (2022). Antiviral metabolite 3′-deoxy-3′, 4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med, 3(3), 204-215.
McGall, G. H., Stubbe, J., & Kozarich, J. W. (1991). Acyl migration in the production of thymine. Propenal from 3′-O-benzoyl-5′-deoxy-4′-(hydroperoxy) thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation. The Journal of Organic Chemistry, 56(1), 48-55.
Bernheim, A., Millman, A., Ofir, G., Meitav, G., Avraham, C., Shomar, H., … & Sorek, R. (2021). Prokaryotic viperins produce diverse antiviral molecules. Nature, 589(7840), 120-124.