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Tenofovir diphosphate – CAS 166403-66-3

Tenofovir diphosphate – CAS 166403-66-3 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

Tenofovir diphosphate triethylammonium salt or sodium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 1200	Stock
5 mg	€ 2800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 1200

Stock

5 mg

€ 2800

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 166403-66-3, 2738719-07-6 (Na+ salt), 2122333-63-3 (Et3NH+ salt)

IUPAC name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

Other names: Tenofovir diphosphate, PMPA-diphosphate, PMPApp

Molecular weight: 447.17 g/mol

Molecular formula: C₉H₁₆N₅O₁₀P₃

InChI: InChI=1S/C9H16N5O10P3/c1-6(2-14-4-13-7-8(10)11-3-12-9(7)14)22-5-25(15,16)23-27(20,21)24-26(17,18)19/h3-4,6H,2,5H2,1H3,(H,15,16)(H,20,21)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1

Description

Tenofovir diphosphate is a metabolite of tenofovir. Tenofovir is a nucleotide analog reverse-transcriptase inhibitor (NtRTI). It selectively inhibits viral reverse transcriptase, a crucial enzyme in retroviruses such as human immunodeficiency virus (HIV), while showing limited inhibition of human enzymes, such as DNA polymerases α, β, and mitochondrial DNA polymerase γ.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Castillo-Mancilla, J. R., Zheng, J. H., Rower, J. E., Meditz, A., Gardner, E. M., Predhomme, J., … & Anderson, P. L. (2013). Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS research and human retroviruses, 29(2), 384-390.
Anderson, P. L., Liu, A. Y., Castillo-Mancilla, J. R., Gardner, E. M., Seifert, S. M., McHugh, C., … & MaWhinney, S. (2018). Intracellular tenofovir-diphosphate and emtricitabine-triphosphate in dried blood spots following directly observed therapy. Antimicrobial agents and chemotherapy, 62(1), 10-1128.
Robbins, B. L., Srinivas, R. V., Kim, C., Bischofberger, N., & Fridland, A. (1998). Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl) adenine (PMPA), Bis (isopropyloxymethylcarbonyl) PMPA. Antimicrobial agents and chemotherapy, 42(3), 612-617.