Entecavir diphosphate – CAS 1348548-74-2
Entecavir diphosphate – CAS 1348548-74-2 is synthesized by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
min 95%
Package contents
Entecavir diphosphate triethylammonium salt
This compound is for research use only. We do not sell to patients.
Amount
| 1 mg | € 3800 | Stock | ||
| 5 mg | € 8500 | Stock | ||
| Do you want custom amount? | Custom amount | |||
Amount
1 mg
€ 3800
Stock
5 mg
€ 8500
Stock
Do you want custom amount?
Custom amount
Characterisation
CAS: 1348548-74-2
IUPAC name: 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one trihydrogen diphosphate
Other names: ETV DP, Baraclude diphosphate
Molecular weight: 437.24 g/mol
Molecular formula: C12H17N5O9P2
InChI: InChI=1S/C12H17N5O9P2/c1-5-6(3-25-28(23,24)26-27(20,21)22)8(18)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)19/h4,6-8,18H,1-3H2,(H,23,24)(H2,20,21,22)(H3,13,15,16,19)/t6-,7-,8-/m0/s1
Description
Entecavir diphosphate is a metabolite of Entacavit. Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.
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Payment
- Payment terms 30 days net
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References
- Honkoop, P., & De Man, R. A. (2003). Entecavir: a potent new antiviral drug for hepatitis B. Expert opinion on investigational drugs, 12(4), 683-688.
- Shaw, T., & Locarnini, S. (2004). Entecavir for the treatment of chronic hepatitis B. Expert review of anti-infective therapy, 2(6), 853-871.
- Zoulim, F. (2006). Entecavir: a new treatment option for chronic hepatitis B. Journal of clinical virology, 36(1), 8-12.
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