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Emtricitabine triphosphate – CAS 145819-92-7

Emtricitabine triphosphate – CAS 145819-92-7 is synthesised by Sigut Labs (Prague, Czech Republic)

Purity (LC-MS)

99%+

Package contents

Emtricitabine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 700	Stock
5 mg	€ 1400	Stock
10 mg	€ 2500	Stock
100mM/10μL	€ 700	Stock
10mM/100μL	€ 700	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 700

Stock

5 mg

€ 1400

Stock

View more amounts

Characterisation

CAS: 145819-92-7, 2736455-57-3 (Et3NH+ salt)

IUPAC name: Triphosphoric acid, P-[[(2R,5S)-5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] ester (Et₃NH⁺ salt)

Other names: Emtricitabine triphosphate, Emtricitabine TP

Molecular weight: 487.19 g/mol

Molecular formula: C₈H₁₃FN₃O₁₂P₃S

InChI: InChI=1S/C8H13FN3O12P3S/c9-4-1-12(8(13)11-7(4)10)5-3-28-6(22-5)2-21-26(17,18)24-27(19,20)23-25(14,15)16/h1,5-6H,2-3H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16)/t5-,6+/m0/s1

Description

Emtricitabine (commonly called FTC, systematic name 2′,3′-dideoxy-5-fluoro-3′-thiacytidine), with trade name Emtriva (formerly Coviracil), is a nucleoside reverse-transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in adults and children.

Emtricitabine is also marketed in a fixed-dose combination with tenofovir disoproxil (Viread) under the brand name Truvada, and with tenofovir alafenamide (Vemlidy) under the brand name Descovy.

A fixed-dose triple combination of emtricitabine, tenofovir and efavirenz (Sustiva, marketed by Bristol-Myers Squibb) was approved by the U.S. Food and Drug Administration (FDA) on July 12, 2006, under the brand name Atripla.

You can find more information about antiviral drug research at Sigut Labs in our article.

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Payment

Payment terms 30 days net
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References

Anderson, P. L., Liu, A. Y., Castillo-Mancilla, J. R., Gardner, E. M., Seifert, S. M., McHugh, C., … & MaWhinney, S. (2018). Intracellular tenofovir-diphosphate and emtricitabine-triphosphate in dried blood spots following directly observed therapy. Antimicrobial agents and chemotherapy, 62(1), 10-1128.
Bang, L. M., & Scott, L. J. (2003). Emtricitabine: an antiretroviral agent for HIV infection. Drugs, 63, 2413-2424.
Zheng, J. H., Rower, C., McAllister, K., Castillo-Mancilla, J., Klein, B., Meditz, A., … & Anderson, P. L. (2016). Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 122, 16-20.
Hawkins, T., Veikley, W., Claire III, R. L. S., Guyer, B., Clark, N., & Kearney, B. P. (2005). Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. JAIDS Journal of Acquired Immune Deficiency Syndromes, 39(4), 406-411.