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Clofarabine triphosphate – CAS 134646-41-6

Clofarabine triphosphate – CAS 134646-41-6 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Clofarabine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 500	Stock
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Amount

1 mg

€ 500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 134646-41-6

IUPAC name: [[(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Other names: Clofarabine-5′-triphosphate;

Molecular weight: 543.62 g/mol

Molecular formula: C₁₀H₁₄ClFN₅O₁₂P₃

InChI: InChI=1S/C10H14ClFN5O12P3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(18)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-4,6,9,18H,1H2,(H,22,23)(H,24,25)(H2,13,15,16)(H2,19,20,21)/t3-,4+,6-,9-/m1/s1

Description

Clofarabine triphosphate is the active metabolite of Clofarabine, a nucleoside analog, used to treat cancers such as leukemia, lymphoma, and solid tumors. Clofarabine has been demonstrated to cause low harm in healthy cells and is generally well tolerated by patients. It inhibits DNA synthesis in rapidly dividing cells. This effect can work in conjunction with other anti-cancer drugs, such as the cytotoxic agent Bleomycin. Clofarabine binds to an intracellular target, preventing DNA synthesis by inhibiting the enzyme DNA polymerase. Inhibition of this enzyme causes cell death. Clofarabine has been studied on pediatric patients ranging in age from one month to 18 years. The medicine has been determined to be safe for use in this demographic.

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Payment

Payment terms 30 days net
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References

Gandhi, V., Kantarjian, H., Faderl, S., Bonate, P., Du, M., Ayres, M., … & Plunkett, W. (2003). Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Clinical cancer research, 9(17), 6335-6342.
Zhenchuk, A., Lotfi, K., Juliusson, G., & Albertioni, F. (2009). Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochemical pharmacology, 78(11), 1351-1359.