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Clevudine triphosphate – CAS 174625-00-4

Clevudine triphosphate – CAS 174625-00-4 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

99%+

Package contents

Clevudine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 800	Stock
5 mg	€ 3500	Stock
10 mg	€ 6500	Stock
100mM/10μL	€ 800	Stock
10mM/100μL	€ 800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 800

Stock

5 mg

€ 3500

Stock

View more amounts

Characterisation

CAS: 174625-00-4, 2736455-58-4 (Et3NH+ salt)

IUPAC name: [[(2S,3S,4R,5S)-4-fluoro-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Other names: Clevudine triphosphate, Clevudine TP

Molecular weight: 500.16 g/mol

Molecular formula: C₁₀H₁₆FN₂O₁₄P₃

InChI: InChI=1S/C10H16FN2O14P3/c1-4-2-13(10(16)12-8(4)15)9-6(11)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,14H,3H2,1H3,(H,20,21)(H,22,23)(H,12,15,16)(H2,17,18,19)/t5-,6+,7-,9-/m0/s1

Description

Clevudine (INN) is an antiviral drug for the treatment of hepatitis B (HBV). It is already approved for HBV in South Korea and the Philippines. It is marketed by Bukwang Pharmaceuticals in South Korea under the tradenames Levovir and Revovir.

Researchers in South Korea are testing clevudine at lower doses in combination with adefovir for continued use.

You can find more information about antiviral drug research at Sigut Labs in our article.

Chemicals are distributed worldwide

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Chong, Y., & Chu, C. K. (2002). Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies. Bioorganic & Medicinal Chemistry Letters, 12(23), 3459-3462.
Yoo, B. C., Kim, J. H., Chung, Y. H., Lee, K. S., Paik, S. W., Ryu, S. H., … & Lee, H. S. (2007). Twenty‐four‐week clevudine therapy showed potent and sustained antiviral activity in HBeAg‐positive chronic hepatitis B. Hepatology, 45(5), 1172-1178.
Menéndez-Arias, L., Álvarez, M., & Pacheco, B. (2014). Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. Current opinion in virology, 8, 1-9.