(-)-Carbovir diphosphate – CAS 129895-89-2

(-)-Carbovir diphosphate – CAS 129895-89-2 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

(-)-Carbovir diphosphate Et3NH+ salt

This compound is for research use only. We do not sell to patients.

 

Amount
1 mg
€ 800

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Amount
1 mg
€ 800

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Do you want custom amount?
Custom amount

Characterisation

CAS: 129895-89-2
IUPAC name: [(1S,4R)-4-(2-amino-6-oxo-1H-purin-9-yl)cyclopent-2-en-1-yl]methyl phosphono hydrogen phosphate
Other names: (-)-CBV-DP  
Molecular weight: 407.21 g/mol
Molecular formula: C11H15N5O8P2
InChI: InChI=1S/C11H15N5O8P2/c12-11-14-9-8(10(17)15-11)13-5-16(9)7-2-1-6(3-7)4-23-26(21,22)24-25(18,19)20/h1-2,5-7H,3-4H2,(H,21,22)(H2,18,19,20)(H3,12,14,15,17)/t6-,7+/m1/s1

Description

(-)-Carbovir diphosphate, also known as (-)-CBV-DP, is a metabolite of drug Carbovir with acitivity against Human Immunodeficiency Virus (HIV).

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References

  • Hawkins, T., Veikley, W., Claire III, R. L. S., Guyer, B., Clark, N., & Kearney, B. P. (2005). Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. JAIDS Journal of Acquired Immune Deficiency Syndromes39(4), 406-411.
  • White, E. L., Parker, W. B., Macy, L. J., Shaddix, S. C., McCaleb, G., Secrist III, J. A., … & Shannon, W. M. (1989). Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases. Biochemical and biophysical research communications161(2), 393-398.
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