Tenofovir monophosphate – CAS 206646-04-0
Tenofovir monophosphate – CAS 206646-04-0 is synthesized by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
min 95%
Package contents
Tenofovir monophosphate triethylammonium salt
This compound is for research use only. We do not sell to patients.
Amount
| 1 mg | € 1250 | Stock | ||
| 5 mg | € 3000 | Stock | ||
| Do you want custom amount? | Custom amount | |||
Amount
1 mg
€ 1250
Stock
5 mg
€ 3000
Stock
Do you want custom amount?
Custom amount
Characterisation
CAS: 206646-04-0
IUPAC name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phosphonooxyphosphinic acid
Other names: Tenofovir phosphate, PMPA-monophosphate
Molecular weight: 367.19 g/mol
Molecular formula: C9H15N5O7P2
InChI: InChI=1S/C9H15N5O7P2/c1-6(20-5-22(15,16)21-23(17,18)19)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H,15,16)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1
Description
Tenofovir monophosphate is a metabolite of tenofovir. Tenofovir is a nucleotide analog reverse-transcriptase inhibitor (NtRTI). It selectively inhibits viral reverse transcriptase, a crucial enzyme in retroviruses such as human immunodeficiency virus (HIV), while showing limited inhibition of human enzymes, such as DNA polymerases α, β, and mitochondrial DNA polymerase γ.
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References
- Kearney, B. P., Flaherty, J. F., & Shah, J. (2004). Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics. Clinical pharmacokinetics, 43, 595-612.
- Antoniou, T., Park‐Wyllie, L. Y., & Tseng, A. L. (2003). Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(1), 29-43.
- Louissaint, N. A., Cao, Y. J., Skipper, P. L., Liberman, R. G., Tannenbaum, S. R., Nimmagadda, S., … & Hendrix, C. W. (2013). Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue. AIDS research and human retroviruses, 29(11), 1443-1450.
- Ray, A. S., Olson, L., & Fridland, A. (2004). Role of purine nucleoside phosphorylase in interactions between 2′, 3′-dideoxyinosine and allopurinol, ganciclovir, or tenofovir. Antimicrobial agents and chemotherapy, 48(4), 1089-1095.
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