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Telbivudine triphosphate – CAS 152502-95-9

Telbivudine triphosphate – CAS 152502-95-9 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

99%+

Package contents

Telbivudine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 800	Stock
5 mg	€ 3500	Stock
10 mg	€ 6500	Stock
100mM/10μL	€ 800	Stock
10mM/100μL	€ 800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 800

Stock

5 mg

€ 3500

Stock

View more amounts

Characterisation

CAS: 152502-95-9, 207128-24-3 (Et3NH+ salt)

IUPAC name: 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-L-erythro-pentofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Other names: Telbivudine triphosphate, Telbivudine TP

Molecular weight: 428.17 g/mol

Molecular formula: C₁₀H₁₇N₂O₁₄P₃

InChI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1

Description

Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (European Union) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. However, HBV signature resistance mutation M204I (a change from methionine to isoleucine at position 204 in the reverse transcriptase domain of the hepatitis B polymerase) or L180M+M204V have been associated with Telbivudine resistance.

Telbivudine is a synthetic thymidine β-L-nucleoside analogue; it is the L-isomer of thymidine. Telbivudine impairs hepatitis B virus (HBV) DNA replication by leading to chain termination. It differs from the natural nucleotide only with respect to the location of the sugar and base moieties, taking on a levorotatory configuration versus a dextrorotatory configuration as do the natural deoxynucleosides

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Payment

Payment terms 30 days net
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References

Lai, C. L., Leung, N., Teo, E. K., Tong, M., Wong, F., Hann, H. W., … & Telbivudine Phase II Investigator Group. (2005). A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen—positive chronic hepatitis B. Gastroenterology, 129(2), 528-536.
Lai, C. L., Gane, E., Liaw, Y. F., Hsu, C. W., Thongsawat, S., Wang, Y., … & Brown, N. A. (2007). Telbivudine versus lamivudine in patients with chronic hepatitis B. New England Journal of Medicine, 357(25), 2576-2588.