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Adefovir monophosphate – CAS 129556-87-2

Adefovir monophosphate – CAS 129556-87-2 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

Adefovir monophosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 450	Stock
5 mg	€ 800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 450

Stock

5 mg

€ 800

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 129556-87-2

IUPAC name: 2-(6-aminopurin-9-yl)ethoxymethyl-phosphonooxyphosphinic acid

Other names: 46TMW03MNX, Adefovir phosphate

Molecular weight: 353.17 g/mol

Molecular formula: C₈H₁₃N₅O₇P₂

InChI: InChI=1S/C8H13N5O7P2/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-19-5-21(14,15)20-22(16,17)18/h3-4H,1-2,5H2,(H,14,15)(H2,9,10,11)(H2,16,17,18)

Description

Adefovir monophosphate is a metabolite of adefovir. An antiviral acyclic nucleoside phosphonate (ANP) analog known as adefovir monophosphate has activity against the herpes, hepatitis B, and human immunodeficiency viruses (HIV). For the treatment of hepatitis B, it is an oral acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that inhibits reverse transcriptase.

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Payment

Payment terms 30 days net
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References

Shen, Y., Zhukovskaya, N. L., Zimmer, M. I., Soelaiman, S., Bergson, P., Wang, C. R., … & Tang, W. J. (2004). Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proceedings of the National Academy of Sciences, 101(9), 3242-3247.
Gu, Z., Salomon, H., Cherrington, J. M., Mulato, A. S., Chen, M. S., Yarchoan, R., … & Wainberg, M. A. (1995). K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl) adenine. Antimicrobial agents and chemotherapy, 39(8), 1888-1891.
Birkuš, G., Votruba, I., Holý, A., & Otová, B. (1999). 9-[2-(phosphonomethoxy) ethyl] adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε∗. Biochemical pharmacology, 58(3), 487-492.