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5-Iodo-2′-deoxyuridine – CAS 54-42-2

5-Iodo-2′-deoxyuridine – CAS 54-42-2 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

98%+

Package contents

5-Iodo-2′-deoxyuridine

This compound is for research use only. We do not sell to patients.

Amount

10 g	€ 300	Stock
25 g	€ 500	Stock
Do you want custom amount?			Custom amount

Amount

10 g

€ 300

Stock

25 g

€ 500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 54-42-2

IUPAC name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

Other names: dIU; Idoxuridine; Allergan 211

Molecular weight: 354.10 g/mol

Molecular formula: C₉H₁₁IN₂O₅

InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

Description

5-Iodo-2′-deoxyuridine (Idoxuridine) is a uridine analogue that prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses. It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties. 5-Iodo-2′-deoxyuridine, used in topical applications, is effective against epithelial infections.

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Payment

Payment terms 30 days net
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References

Benson III, A. B., Trump, D. L., Cummings, K. B., & Fischer, P. H. (1985). Modulation of 5-iodo-2′-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines. Biochemical pharmacology, 34(21), 3925-3931.
Fischer, P. H., Chen, M. S., & Prusoff, W. H. (1980). The incorporation of 5-iodo-5′-amino-2′, 5′-dideoxyuridine and 5-iodo-2′-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure. Biochimica et Biophysica Acta (BBA)-Nucleic Acids and Protein Synthesis, 606(2), 236-245.
Prusoff, W. H., & Chang, P. K. (1968). 5-Iodo-2 ‘-deoxyuridine 5 ‘-Triphosphate, an Allosteric Inhibitor of Deoxycytidylate Deaminase. Journal of Biological Chemistry, 243(2), 223-230.