5-Iodo-2′-deoxyuridine – CAS 54-42-2
5-Iodo-2′-deoxyuridine – CAS 54-42-2 is synthesised by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
98%+
Package contents
5-Iodo-2′-deoxyuridine
This compound is for research use only. We do not sell to patients.
Amount
10 g | € 300 | Stock | ||
25 g | € 500 | Stock | ||
Do you want custom amount? | Custom amount |
Amount
10 g
€ 300
Stock
25 g
€ 500
Stock
Do you want custom amount?
Custom amount
Characterisation
CAS: 54-42-2
IUPAC name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
Other names: dIU; Idoxuridine; Allergan 211
Molecular weight: 354.10 g/mol
Molecular formula: C9H11IN2O5
InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
Description
5-Iodo-2′-deoxyuridine (Idoxuridine) is a uridine analogue that prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses. It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties. 5-Iodo-2′-deoxyuridine, used in topical applications, is effective against epithelial infections.
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Payment
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References
- Benson III, A. B., Trump, D. L., Cummings, K. B., & Fischer, P. H. (1985). Modulation of 5-iodo-2′-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines. Biochemical pharmacology, 34(21), 3925-3931.
- Fischer, P. H., Chen, M. S., & Prusoff, W. H. (1980). The incorporation of 5-iodo-5′-amino-2′, 5′-dideoxyuridine and 5-iodo-2′-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure. Biochimica et Biophysica Acta (BBA)-Nucleic Acids and Protein Synthesis, 606(2), 236-245.
- Prusoff, W. H., & Chang, P. K. (1968). 5-Iodo-2 ‘-deoxyuridine 5 ‘-Triphosphate, an Allosteric Inhibitor of Deoxycytidylate Deaminase. Journal of Biological Chemistry, 243(2), 223-230.
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