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5-Hydroxymethyl-2′-deoxyuridine – CAS 5116-24-5

5-Hydroxymethyl-2′-deoxyuridine – CAS 5116-24-5 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

95%+

Package contents

This compound is for research use only. We do not sell to patients.

Amount

100 mg	€ 850	Stock
250 mg	€ 1000	Stock
Do you want custom amount?			Custom amount

Amount

100 mg

€ 850

Stock

250 mg

€ 1000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 5116-24-5

IUPAC name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(hydroxymethyl)pyrimidine-2,4-dione

Other names: alpha-Hydroxythymidine; HMdU;

Molecular weight: 258.23 g/mol

Molecular formula: C₁₀H₁₄N₂O₆

InChI: InChI=1S/C10H14N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2,6-8,13-15H,1,3-4H2,(H,11,16,17)/t6-,7+,8+/m0/s1

Description

5-(Hydroxymethyl)-2′-deoxyuridine is a nucleoside analog with both anticancer and antiviral properties. It suppresses the replication of murine S180 lung cancer cells, Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively), and various human leukemia cell lines (IC50s = 1.7-5.8 μM).

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Payment

Payment terms 30 days net
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References

Litosh, V. A., Wu, W., Stupi, B. P., Wang, J., Morris, S. E., Hersh, M. N., & Metzker, M. L. (2011). Improved nucleotide selectivity and termination of 3′-OH unblocked reversible terminators by molecular tuning of 2-nitrobenzyl alkylated HOMedU triphosphates. Nucleic acids research, 39(6), e39-e39.
Evans, M. D., Saparbaev, M., & Cooke, M. S. (2010). DNA repair and the origins of urinary oxidized 2′-deoxyribonucleosides. Mutagenesis, 25(5), 433-442.