Home → E-shop → Antiviral compounds → 3′,4′-Didehydro-3′-deoxyadenosine – CAS 42867-61-8

3′,4′-Didehydro-3′-deoxyadenosine – CAS 42867-61-8

3′,4′-Didehydro-3′-deoxyadenosine – CAS 42867-61-8 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxyadenosine

This compound is for research use only. We do not sell to patients.

Amount

10 mg	€ 400	Stock
100 mg	€ 1500	Stock
500 mg	€ 3000	Stock
Do you want custom amount?			Custom amount

Amount

10 mg

€ 400

Stock

100 mg

€ 1500

Stock

View more amounts

Characterisation

CAS: 42867-61-8

IUPAC name: 3′,4′-Didehydro-3′-deoxyadenosine

Other names: DdhA, Ddh-A

Molecular weight: 249.23 g/mol

Molecular formula: C₁₀H₁₁N₅O₃

InChI: InChI=1S/C10H11N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h1,3-4,6,10,16-17H,2H2,(H2,11,12,13)/t6-,10-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyadenosine is an analogue of adenosine. A related compound, 3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

This product was developed as part of the European Union-funded grant program Czech Rise Up 3.0 – Výzkum medicínských řešení v době digitalizace.

References

Magnusson, O. T., & Frey, P. A. (2000). Synthesis and Characterization of 3 ‘, 4 ‘-Anhydroadenosylcobalamin: A Coenzyme B12 Analogue with Unusual Properties. Journal of the American Chemical Society, 122(37), 8807-8813.
Petrová, M., Buděšínský, M., & Rosenberg, I. (2010). Straightforward synthesis of 3′-deoxy-3′, 4′-didehydronucleoside-5′-aldehydes via 2′, 3′-O-orthoester group elimination: a simple route to 3′, 4′-didehydronucleosides. Tetrahedron Letters, 51(52), 6874-6876.