3′,4′-Didehydro-3′-deoxyuridine – CAS 26301-98-4

3′,4′-Didehydro-3′-deoxyuridine – CAS 26301-98-4 is synthesized by Sigut Labs (Prague, Czech Republic). 

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxyuridine

This compound is for research use only. We do not sell to patients.
Amount
10 mg
€ 400

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100 mg
€ 1500

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500 mg
€ 3000

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Amount
10 mg
€ 400

Stock

100 mg
€ 1500

Stock

500 mg
€ 3000

Stock

View more amounts
Do you want custom amount?
Custom amount

Characterisation

CAS: 26301-98-4
IUPAC name: 1-((2R,3R)-3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Other names: DdhU, Ddh-U, 3′,4′-Didehydro-3′-deoxyuridine (ACI)
Molecular weight: 226.19 g/mol
Molecular formula: C9H10N2O5
InChI: InChI=1S/C9H10N2O5/c12-4-5-3-6(13)8(16-5)11-2-1-7(14)10-9(11)15/h1-3,6,8,12-13H,4H2,(H,10,14,15)/t6-,8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyuridine is an analogue of uridine. A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

This product was developed as part of the European Union-funded grant program Czech Rise Up 3.0 – Výzkum medicínských řešení v době digitalizace.

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Payment

  • We are sending the invoice the same day as the shipment
  • We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

  • Petrová, M., Buděšínský, M., & Rosenberg, I. (2010). Straightforward synthesis of 3′-deoxy-3′, 4′-didehydronucleoside-5′-aldehydes via 2′, 3′-O-orthoester group elimination: a simple route to 3′, 4′-didehydronucleosides. Tetrahedron Letters51(52), 6874-6876.
  • WO2020202142 A2 2020-10-08
  • US3457255 A 1969-07-22
  • WO2022038539 A2 2022-02-24
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