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3′,4′-Didehydro-3′-deoxythymidine – CAS 37782-89-1

3′,4′-Didehydro-3′-deoxythymidine – CAS 37782-89-1 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxythymidine

This compound is for research use only. We do not sell to patients.

Amount

10 mg	€ 400	Stock
100 mg	€ 1500	Stock
500 mg	€ 3000	Stock
Do you want custom amount?			Custom amount

Amount

10 mg

€ 400

Stock

100 mg

€ 1500

Stock

View more amounts

Characterisation

CAS: 37782-89-1

IUPAC name: 1-[(2R)-2,3-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Other names: DdhT, Ddh-T,

Molecular weight: 224.21 g/mol

Molecular formula: C₁₀H₁₂N₂O₄

InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2,4,8,13H,3,5H2,1H3,(H,11,14,15)/t8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxythymidine is an analogue of thymidine. A related compound, 3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

This product was developed as part of the European Union-funded grant program Czech Rise Up 3.0 – Výzkum medicínských řešení v době digitalizace.

Chemicals are distributed worldwide

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Payment

Payment terms 30 days net
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References

McGall, G. H., Stubbe, J., & Kozarich, J. W. (1991). Acyl migration in the production of thymine. Propenal from 3′-O-benzoyl-5′-deoxy-4′-(hydroperoxy) thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation. The Journal of Organic Chemistry, 56(1), 48-55.
Pratviel, G., Pitié, M., Périgaud, C., Gosselin, G., Bernadou, J., & Meunier, B. (1993). Identification of sugar degradation intermediates in a metalloporphyrin mediated DNA cleavage resulting from hydroxylation at C-5′. Journal of the Chemical Society, Chemical Communications, (2), 149-151.