3′,4′-Didehydro-3′-deoxycytidine triphosphate – CAS 2279171-34-3

3′,4′-Didehydro-3′-deoxycytidine triphosphate – CAS 2279171-34-3 is synthesized by Sigut Labs (Prague, Czech Republic). 

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxycytidine triphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount
1 mg
€ 1000

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5 mg
€ 2500

Stock

Do you want custom amount?
Custom amount
Amount
1 mg
€ 1000

Stock

5 mg
€ 2500

Stock

Do you want custom amount?
Custom amount

Characterisation

CAS: 2279171-34-3, 2657712-17-7 ( Et3NH+ salt)
IUPAC name: 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-4-Amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]-1,2-dihydropyrimidin-2-one triphosphate
Other names: 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-2(1H)-Pyrimidinone Triphosphate, DdhCTP, DdhC-TP
Molecular weight: 465.15 g/mol
Molecular formula: C9H14N3O13P3
InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2,4,8,13H,3,5H2,1H3,(H,11,14,15)/t8-/m1/s1

Description

3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have an antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

3′,4′-didehydro-3′-deoxycytidine triphosphate is provided as triethylammonium salt.

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Payment

  • We are sending the invoice the same day as the shipment
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References

  • Wang, F. (2007). Unsaturated Didehydrodeoxycytidine Drugs. 1. Impact of CC Positions in the Sugar Ring. The Journal of Physical Chemistry B111(32), 9628-9633.
  • Torrance, C. J., Agrawal, V., Vogelstein, B., & Kinzler, K. W. (2001). Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nature biotechnology19(10), 940-945.
  • Mehta, R., Chekmeneva, E., Jackson, H., Sands, C., Mills, E., Arancon, D., … & Sriskandan, S. (2022). Antiviral metabolite 3′-deoxy-3′, 4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med3(3), 204-215.
  • McGall, G. H., Stubbe, J., & Kozarich, J. W. (1991). Acyl migration in the production of thymine. Propenal from 3′-O-benzoyl-5′-deoxy-4′-(hydroperoxy) thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation. The Journal of Organic Chemistry56(1), 48-55.
  • Bernheim, A., Millman, A., Ofir, G., Meitav, G., Avraham, C., Shomar, H., … & Sorek, R. (2021). Prokaryotic viperins produce diverse antiviral molecules. Nature589(7840), 120-124.
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