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Zidovudine triphosphate – CAS 92586-35-1

Zidovudine triphosphate – CAS 92586-35-1 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Zidovudine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 450	Stock
5 mg	€ 1100	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 450

Stock

5 mg

€ 1100

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 92586-35-1

IUPAC name: [[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Other names: AZT triphosphate, AZT-TP, dTTP(3’N3), Combivir

Molecular weight: 507.18 g/mol

Molecular formula: C₁₀H₁₆N₅O₁₃P₃

InChI: InChI=1S/C10H16N5O13P3/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h3,6-8H,2,4H2,1H3,(H,21,22)(H,23,24)(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1

Description

Zidovudine, also known as AZT, is a medication used to treat HIV infections. Once inside cells, enzymes convert AZT into its active form, AZT triphosphate (AZT TP). This active metabolite has several key effects:

Fights HIV: AZT TP blocks the replication of HIV by interfering with an enzyme called reverse transcriptase, crucial for the virus to make copies of itself.
Inhibits HBV: In addition to HIV, AZT TP can also inhibit the DNA polymerase enzyme used by the Hepatitis B virus (HBV).
Cell Death Pathway: At high concentrations, AZT TP can trigger a cellular suicide program known as the mitochondria-mediated apoptosis pathway.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Marquez, V. E., Ezzitouni, A., Russ, P., Siddiqui, M. A., Ford, H., Feldman, R. J., … & Barchi, J. J. (1998). HIV-1 reverse transcriptase can discriminate between two conformationally locked carbocyclic AZT triphosphate analogues. Journal of the American Chemical Society, 120(12), 2780-2789.
Lavie, A., Schlichting, I., Vetter, I. R., Konrads, M., Reinstein, J., & Goody, R. S. (1997). The bottleneck in AZT activation. Nature medicine, 3(8), 922-924.
Frick, L. W., Nelson, D. J., Clair, M. H. S., Furman, P. A., & Krenitsky, T. A. (1988). Effects of 3′-azido-3′-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells. Biochemical and biophysical research communications, 154(1), 124-129.