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Zidovudine monophosphate – CAS 29706-85-2

Zidovudine monophosphate – CAS 29706-85-2 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Zidovudine monophosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 300	Stock
5 mg	€ 800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 300

Stock

5 mg

€ 800

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 29706-85-2

IUPAC name: [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

Other names: AZT monophosphate, AZT-MP, dTMP(3’N3)

Molecular weight: 347.22 g/mol

Molecular formula: C₁₀H₁₄N₅O₇P

InChI: InChI=1S/C10H14N5O7P/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(22-8)4-21-23(18,19)20/h3,6-8H,2,4H2,1H3,(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1

Description

Zidovudine, also known as AZT, is a medication used to treat HIV infections. Once inside cells, enzymes convert AZT into its active form, AZT triphosphate (AZT TP). This active metabolite has several key effects:

Fights HIV: AZT TP blocks the replication of HIV by interfering with an enzyme called reverse transcriptase, crucial for the virus to make copies of itself.
Inhibits HBV: In addition to HIV, AZT TP can also inhibit the DNA polymerase enzyme used by the Hepatitis B virus (HBV).
Cell Death Pathway: At high concentrations, AZT TP can trigger a cellular suicide program known as the mitochondria-mediated apoptosis pathway.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
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References

Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., … & Mitsuya, H. (1986). Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proceedings of the National Academy of Sciences, 83(21), 8333-8337.