Home → E-shop → Nucleotides → Zidovudine diphosphate – CAS 106060-89-3

Zidovudine diphosphate – CAS 106060-89-3

Zidovudine diphosphate – CAS 106060-89-3 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Zidovudine diphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 600	Stock
5 mg	€ 1500	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 600

Stock

5 mg

€ 1500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 106060-89-3

IUPAC name: [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate

Other names: AZT diphosphate, AZT-DP, dTDP(3’N3)

Molecular weight: 427.20 g/mol

Molecular formula: C₁₀H₁₅N₅O₁₀P₂

InChI: InChI=1S/C10H15N5O10P2/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(24-8)4-23-27(21,22)25-26(18,19)20/h3,6-8H,2,4H2,1H3,(H,21,22)(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1

Description

Zidovudine, also known as AZT, is a medication used to treat HIV infections. Once inside cells, enzymes convert AZT into its active form, AZT triphosphate (AZT TP). This active metabolite has several key effects:

Fights HIV: AZT TP blocks the replication of HIV by interfering with an enzyme called reverse transcriptase, crucial for the virus to make copies of itself.
Inhibits HBV: In addition to HIV, AZT TP can also inhibit the DNA polymerase enzyme used by the Hepatitis B virus (HBV).
Cell Death Pathway: At high concentrations, AZT TP can trigger a cellular suicide program known as the mitochondria-mediated apoptosis pathway.

Chemicals are distributed worldwide

Buy Zidovudine diphosphate now, and get your order in 48 hours

Shipping through DHL in 48 hours
Sensitive compounds are shipped on dry ice
All compounds are safely and rigorously packed

Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., … & Mitsuya, H. (1986). Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proceedings of the National Academy of Sciences, 83(21), 8333-8337.