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Undecynyl-dUTP – CAS 2229952-07-0

Undecynyl-dUTP – CAS 2229952-07-0 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Undecynyl-dUTP Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 1	Stock
5 mg	€ 3000	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 1

Stock

5 mg

€ 3000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 2229952-07-0

IUPAC name: α-(undec-10-yn-1-yloxy)thymidine-5’-O-triphosphate triethylamine salt

Other names: Undecynyl-dUTP

Molecular weight: 952.10 g/mol

Molecular formula: C₂₁H₃₅N₂O₁₅P₃*3C₆H₁₅N

InChI: InChI=1S/C21H35N2O15P3/c1-2-3-4-5-6-7-8-9-10-11-34-14-16-13-23(21(26)22-20(16)25)19-12-17(24)18(36-19)15-35-40(30,31)38-41(32,33)37-39(27,28)29/h1,13,17-19,24H,3-12,14-15H2,(H,30,31)(H,32,33)(H,22,25,26)(H2,27,28,29)/t17-,18+,19+/m0/s1

Description

These nucleotide bear alkyne linked to pyrimidine through long flexible linkers, and were previously designed in Michal Hocek group at IOCB (https://pubs.acs.org/doi/10.1021/acs.orglett.8b01533). Undecynyl-dUTP has a hydrophobic tether. It is a great substrate for KOD XL polymerase and other DNA polymerases in PEX and PCR amplification, while the flexibility and length of linked alkynes provide a significant advantage for the reactivity in CuAAC of the alkynyl-modified DNA.

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Payment

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References

Panattoni, A., Pohl, R., & Hocek, M. (2018). Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1, 3-Dipolar Cycloaddition. Organic letters, 20(13), 3962-3965.