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Troxacitabine monophosphate – CAS 182482-78-6

Troxacitabine monophosphate – CAS 182482-78-6 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Troxacitabine monophosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 4000	Stock
Do you want custom amount?				Custom amount

Amount

1 mg

€ 4000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 182482-78-6

IUPAC name: [(2S,4S)-4-(4-amino-2-oxopyrimidin-1-yl)-1,3-dioxolan-2-yl]methyl dihydrogen phosphate

Other names: L-OddCMP

Molecular weight: 293.17 g/mol

Molecular formula: C₈H₁₂N₃O₇P

InChI: InChI=1S/C8H12N3O7P/c9-5-1-2-11(8(12)10-5)6-3-16-7(18-6)4-17-19(13,14)15/h1-2,6-7H,3-4H2,(H2,9,10,12)(H2,13,14,15)/t6-,7-/m0/s1

Description

Troxacitabine monophosphate is the metabolite of a drug called Troxacitabine. Its use is being studied in patients with refractory lymphoproliferative diseases.

Chemicals are distributed worldwide

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Gourdeau, H., Clarke, M. L., Ouellet, F., Mowles, D., Selner, M., Richard, A., … & Cass, C. E. (2001). Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. Cancer research, 61(19), 7217-7224.
Sabini, E., Hazra, S., Konrad, M., Burley, S. K., & Lavie, A. (2007). Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic acids research, 35(1), 186-192.
Bouffard, D. Y., Jolivet, J., Leblond, L., Hamelin, B., Ouellet, F., Barbeau, S., … & Gourdeau, H. (2003). Complementary antineoplastic activity of the cytosine nucleoside analogues troxacitabine (Troxatyl) and cytarabine in human leukemia cells. Cancer chemotherapy and pharmacology, 52, 497-506.