Troxacitabine diphosphate – CAS 182482-79-7
Troxacitabine diphosphate – CAS 182482-79-7 is synthesised by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
97%+
Package contents
Troxacitabine diphosphate Et3NH+ salt
This compound is for research use only. We do not sell to patients.
Amount
| 1 mg | € 5000 | Stock | ||
| Do you want custom amount? | Custom amount | |||
Amount
1 mg
€ 5000
Stock
Do you want custom amount?
Custom amount
Characterisation
CAS: 182482-79-7
IUPAC name: ((2S,4S)-4-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-dioxolan-2-yl)methyl trihydrogen diphosphate
Other names: L-OddCDP
Molecular weight: 373.15 g/mol
Molecular formula: C8H13N3O10P2
InChI: InChI=1S/C8H13N3O10P2/c9-5-1-2-11(8(12)10-5)6-3-18-7(20-6)4-19-23(16,17)21-22(13,14)15/h1-2,6-7H,3-4H2,(H,16,17)(H2,9,10,12)(H2,13,14,15)/t6-,7-/m0/s1
Description
Troxacitabine diphosphate is the metabolite of a drug called Troxacitabine. Its use is being studied in patients with refractory lymphoproliferative diseases.
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Payment
- Payment terms 30 days net
- We are sending the invoice the same day as the shipment
- We are able to modify the invoice for the academic institution, so the order can be paid from grants
References
- Gourdeau, H., Clarke, M. L., Ouellet, F., Mowles, D., Selner, M., Richard, A., … & Cass, C. E. (2001). Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines. Cancer research, 61(19), 7217-7224.
- Sabini, E., Hazra, S., Konrad, M., Burley, S. K., & Lavie, A. (2007). Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic acids research, 35(1), 186-192.
- Bouffard, D. Y., Jolivet, J., Leblond, L., Hamelin, B., Ouellet, F., Barbeau, S., … & Gourdeau, H. (2003). Complementary antineoplastic activity of the cytosine nucleoside analogues troxacitabine (Troxatyl) and cytarabine in human leukemia cells. Cancer chemotherapy and pharmacology, 52, 497-506.
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