Remdesivir triphosphate triethylammonium – GS-443902 – CAS 2725956-16-9

Description

Remdesivir triphosphate is synthesised by Sigut Labs (Prague, Czech Republic). GS-443902 is the active triphosphate metabolite of Remdesivir with activity against zoonotic feline infectious peritonitis virus (FIPV) and severe acute respiratory syndrome (SARS) virus from the Coronaviridae family. GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC₅₀s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively.

Remdesivir, developed by Gilead Sciences, is an adenosine prodrug that metabolizes into its active form GS-441524, which interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production.

This product is prepared and shipped as Et3NH+ salt. If you are interested in Na+ salt, visit our product page.

All products are lyophilized and can easily sustain the shipment oversee (shipping with DHL on dry ice to ensure that product arrives in a perfect state).

We are also offering this product as a water solution.

Chemicals are distributed worldwide

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• Shipping through DHL in 48 hours
• Sensitive compounds are shipped on dry ice
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Payment

• Payment terms 30 days net
• We are sending the invoice the same day as the shipment
• We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

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