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PSI-7409 – CAS 1015073-42-3

PSI-7409 – CAS 1015073-42-3 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

98%+

Package contents

PSI-7409 triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 700	Stock
5 mg	€ 1800	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 700

Stock

5 mg

€ 1800

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 1015073-42-3, 1621884-22-7 (Na+ salt), 2144794-62-5 ( Et3NH+ salt)

IUPAC name: (2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine 5′-(tetrahydrogen triphosphate)

Other names: GS 461203, Sofosbuvir triphosphate, Sofosbuvir-TP

Molecular weight: 500.16 g/mol

Molecular formula: C₁₀H₁₆FN₂O₁₄P₃

InChI: InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1

Description

PSI-7409 is the active 5′-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analogue inhibitor of HCV.

Chemicals are distributed worldwide

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Lam, A. M., Murakami, E., Espiritu, C., Steuer, H. M. M., Niu, C., Keilman, M., … & Furman, P. A. (2010). PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrobial agents and chemotherapy, 54(8), 3187-3196.
Murakami, E., Tolstykh, T., Bao, H., Niu, C., Steuer, H. M. M., Bao, D., … & Furman, P. A. (2010). Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. Journal of biological chemistry, 285(45), 34337-34347.
Lam, A. M., Espiritu, C., Bansal, S., Micolochick Steuer, H. M., Niu, C., Zennou, V., … & Furman, P. A. (2012). Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrobial agents and chemotherapy, 56(6), 3359-3368.