Home → E-shop → Nucleotides → N4-Hydroxycytidine monophosphate – CAS 4988-54-9

N4-Hydroxycytidine monophosphate – CAS 4988-54-9

N⁴-Hydroxycytidine monophosphate – CAS 4988-54-9 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

98%+

Package contents

N⁴-Hydroxycytidine monophosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 400	Stock
5 mg	€ 750	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 400

Stock

5 mg

€ 750

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 4988-54-9

IUPAC name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl dihydrogen phosphate

Other names: N4-OH-CMP, N-Hydroxycytidine 5′-(Dihydrogen Phosphate), Molnupiravir monophosphate

Molecular weight: 339.20 g/mol

Molecular formula: C₉H₁₄N₃O₉P

InChI: InChI=1S/C9H14N3O9P/c13-6-4(3-20-22(17,18)19)21-8(7(6)14)12-2-1-5(11-16)10-9(12)15/h1-2,4,6-8,13-14,16H,3H2,(H,10,11,15)(H2,17,18,19)/t4-,6-,7-,8-/m1/s1

Description

N⁴-Hydroxycytidine monophosphate– CAS 4988-54-9 is a metabolite of molnupiravir. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

Chemicals are distributed worldwide

Buy N⁴-Hydroxycytidine monophosphate now, and get your order in 48 hours

Shipping through DHL in 48 hours
Sensitive compounds are shipped on dry ice
All compounds are safely and rigorously packed

Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Hernandez-Santiago, B. I., Beltran, T., Stuyver, L., Chu, C. K., & Schinazi, R. F. (2004). Metabolism of the anti-hepatitis C virus nucleoside β-d-N 4-hydroxycytidine in different liver cells. Antimicrobial agents and chemotherapy, 48(12), 4636-4642.
Urakova, N., Kuznetsova, V., Crossman, D. K., Sokratian, A., Guthrie, D. B., Kolykhalov, A. A., … & Frolov, I. (2018). β-d-N 4-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. Journal of virology, 92(3), 10-1128.
Zhou, S., Hill, C. S., Sarkar, S., Tse, L. V., Woodburn, B. M., Schinazi, R. F., … & Swanstrom, R. (2021). β-D-N 4-hydroxycytidine inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to mammalian cells. The Journal of infectious diseases, 224(3), 415-419.
Agostini, M. L., Pruijssers, A. J., Chappell, J. D., Gribble, J., Lu, X., Andres, E. L., … & Denison, M. R. (2019). Small-molecule antiviral β-d-N 4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of virology, 93(24), 10-1128.