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N4-Hydroxycytidine diphosphate – CAS 39023-73-9

N⁴-Hydroxycytidine diphosphate– CAS 39023-73-9 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

98%+

Package contents

N⁴-Hydroxycytidine diphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 550	Stock
5 mg	€ 900	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 550

Stock

5 mg

€ 900

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 39023-73-9

IUPAC name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl phosphono hydrogen phosphate

Other names: N4-OH-CDP, NHC-diphosphate

Molecular weight: 419.18 g/mol

Molecular formula: C₉H₁₅N₃O₁₂P₂

InChI: InChI=1S/C9H15N3O12P2/c13-6-4(3-22-26(20,21)24-25(17,18)19)23-8(7(6)14)12-2-1-5(11-16)10-9(12)15/h1-2,4,6-8,13-14,16H,3H2,(H,20,21)(H,10,11,15)(H2,17,18,19)/t4-,6-,7-,8-/m1/s1

Description

N⁴-Hydroxycytidine diphosphate– CAS 39023-73-9 is a metabolite of molnupiravir. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

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Payment

Payment terms 30 days net
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References

Hernandez-Santiago, B. I., Beltran, T., Stuyver, L., Chu, C. K., & Schinazi, R. F. (2004). Metabolism of the anti-hepatitis C virus nucleoside β-d-N 4-hydroxycytidine in different liver cells. Antimicrobial agents and chemotherapy, 48(12), 4636-4642.
Urakova, N., Kuznetsova, V., Crossman, D. K., Sokratian, A., Guthrie, D. B., Kolykhalov, A. A., … & Frolov, I. (2018). β-d-N 4-Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. Journal of virology, 92(3), 10-1128.
Zhou, S., Hill, C. S., Sarkar, S., Tse, L. V., Woodburn, B. M., Schinazi, R. F., … & Swanstrom, R. (2021). β-D-N 4-hydroxycytidine inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to mammalian cells. The Journal of infectious diseases, 224(3), 415-419.
Agostini, M. L., Pruijssers, A. J., Chappell, J. D., Gribble, J., Lu, X., Andres, E. L., … & Denison, M. R. (2019). Small-molecule antiviral β-d-N 4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of virology, 93(24), 10-1128.