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Fialuridine triphosphate – CAS 159119-82-1

Fialuridine triphosphate – CAS 159119-82-1 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Fialuridine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 1200	Stock
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Amount

1 mg

€ 1200

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 159119-82-1

IUPAC name: ((2R,3R,4S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Other names: Fialuridine-5′-triphosphate;

Molecular weight: 612.03 g/mol

Molecular formula: C₉H₁₃IFN₂O₁₄P₃

InChI: InChI=1S/C9H13FIN2O14P3/c10-5-6(14)4(25-8(5)13-1-3(11)7(15)12-9(13)16)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,14H,2H2,(H,20,21)(H,22,23)(H,12,15,16)(H2,17,18,19)/t4-,5+,6-,8-/m1/s1

Description

Fialuridine triphosphate is a phosphorylated form of Fialuridine, a compound with potential applications in the fight against Hepatitis B virus (HBV). It might selectively inhibits the HBV polymerase, an enzyme crucial for viral replication. This targeted approach could potentially minimize side effects compared to some existing HBV treatments.

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Payment

Payment terms 30 days net
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References

Lewis, W., Levine, E. S., Griniuviene, B., Tankersley, K. O., Colacino, J. M., Sommadossi, J. P., … & Perrino, F. W. (1996). Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proceedings of the National Academy of Sciences, 93(8), 3592-3597.
Aguesse-Germon, S., Liu, S. H., Chevallier, M., Pichoud, C., Jamard, C., Borel, C., … & Zoulim, F. (1998). Inhibitory effect of 2′-fluoro-5-methyl-β-l-arabinofuranosyl-uracil on duck hepatitis B virus replication. Antimicrobial agents and chemotherapy, 42(2), 369-376.