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Fialuridine diphosphate – CAS 847651-68-7

Fialuridine diphosphate – CAS 847651-68-7 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Fialuridine diphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 1400	Stock
Do you want custom amount?				Custom amount

Amount

1 mg

€ 1400

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 847651-68-7

IUPAC name: ((2R,3R,4S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl trihydrogen diphosphate

Other names: Fialuridine-5′-diphosphate;

Molecular weight: 532.05 g/mol

Molecular formula: C₉H₂₃IFN₂O₁₁P₂

InChI: InChI=1S/C9H12FIN2O11P2/c10-5-6(14)4(2-22-26(20,21)24-25(17,18)19)23-8(5)13-1-3(11)7(15)12-9(13)16/h1,4-6,8,14H,2H2,(H,20,21)(H,12,15,16)(H2,17,18,19)/t4-,5+,6-,8-/m1/s1

Description

Fialuridine diphosphate is a phosphorylated form of Fialuridine, a compound with potential applications in the fight against Hepatitis B virus (HBV). It might selectively inhibits the HBV polymerase, an enzyme crucial for viral replication. This targeted approach could potentially minimize side effects compared to some existing HBV treatments.

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Payment

Payment terms 30 days net
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References

Lewis, W., Levine, E. S., Griniuviene, B., Tankersley, K. O., Colacino, J. M., Sommadossi, J. P., … & Perrino, F. W. (1996). Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proceedings of the National Academy of Sciences, 93(8), 3592-3597.
Aguesse-Germon, S., Liu, S. H., Chevallier, M., Pichoud, C., Jamard, C., Borel, C., … & Zoulim, F. (1998). Inhibitory effect of 2′-fluoro-5-methyl-β-l-arabinofuranosyl-uracil on duck hepatitis B virus replication. Antimicrobial agents and chemotherapy, 42(2), 369-376.