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Exatecan mesylate – CAS 169869-90-3

Exatecan mesylate – CAS 169869-90-3 is provided by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

95%+

Package contents

Exatecan mesylate

This compound is for research use only. We do not sell to patients.

Amount

100 mg	€ 245	Stock
1 g	€ 820	Stock
Do you want custom amount?			Custom amount

Amount

100 mg

€ 245

Stock

1 g

€ 820

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 169869-90-3

IUPAC name: (10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid

Other names: Exatecan mesylate; DX8951f

Molecular weight: 531.55 g/mol

Molecular formula: C₂₅H₂₆FN₃O₇S

InChI: InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m0./s1

Description

Exatecan mesylate inhibits DNA topoisomerase I, having an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate is frequently utilized in cancer research and in antibody-drug conjugate (ADC) production.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Sun, F. X., Tohgo, A., Bouvet, M., Yagi, S., Nassirpour, R., Moossa, A. R., & Hoffman, R. M. (2003). Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer research, 63(1), 80-85.