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CoumFluor-Tz1 – CAS 2594424-82-3

CoumFluor-Tz1 – CAS 2594424-82-3 was synthesized and licensed at the IOCB Prague, lab of Milan Vrábel.

Purity (LC-MS)

95%+

Package contents

CoumFluor-Tz1

This compound is for research use only. We do not sell to patients.

Amount

0.5 mg	€ 350	Stock
1 mg	€ 500	Stock
Do you want custom amount?			Custom amount

Amount

0.5 mg

€ 350

Stock

1 mg

€ 500

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 2594424-82-3

IUPAC name: 7-(azetidin-1-yl)-4-methyl-3-(5-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)-2H-chromen-2-one

Other names: CoumFluor-Tz1

Molecular weight: 450.45 g/mol

Molecular formula: C₂₄H₁₈N₈O₂

InChI: InChI=1S/C24H18N8O2/c1-14-18-5-4-17(32-8-3-9-32)11-19(18)34-24(33)20(14)15-10-16(13-25-12-15)21-28-30-23(31-29-21)22-26-6-2-7-27-22/h2,4-7,10-13H,3,8-9H2,1H3

Description

The compound reacts rapidly in Diels-Alder reactions with strained dienophiles such as trans-cyclooctene (TCO) and bicyclononyne (BCN) producing a fluorescent click product with fluorescence turn-on values of several hundred-fold (λ_abs = 405 nm, λ_Em = 480 nm). This powerful fluorogenic reagent enables no-wash labelling of various dienophile-modified (bio)molecules in living cells.

CoumFluor-Tz1, CAS 2594424-82-3 was synthesized and licensed at the IOCB Prague, lab of Milan Vrábel.

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Payment

Payment terms 30 days net
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References

Galeta, Juraj, et al. “A Systematic Study of Coumarin–Tetrazine Light‐Up Probes for Bioorthogonal Fluorescence Imaging.” Chemistry–A European Journal 26.44 (2020): 9945-9953.
La–Venia, Agustina, et al. “An Optimized Protocol for the Synthesis of Peptides Containing trans‐Cyclooctene and Bicyclononyne Dienophiles as Useful Multifunctional Bioorthogonal Probes.” Chemistry–A European Journal 27.54 (2021): 13632-13641.
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