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Cladribine triphosphate – CAS 106867-30-5

Cladribine triphosphate – CAS 106867-30-5 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

Cladribine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 1750	Stock
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Amount

1 mg

€ 1750

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 106867-30-5

IUPAC name: [[(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Other names: 2-Chloro-2′-deoxyadenosine-5′-triphosphate; 2-CldATP;

Molecular weight: 525.63 g/mol

Molecular formula: C₁₀H₁₅ClN₅O₁₂P₃

InChI: InChI=1S/C10H15ClN5O12P3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(17)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,17H,1-2H2,(H,21,22)(H,23,24)(H2,12,14,15)(H2,18,19,20)/t4-,5+,6+/m0/s1

Description

Cladribine triphosphate is the active form of cladribine, a medication used to treat hairy cell leukemia and multiple sclerosis. Cladribine triphosphate interferes with DNA replication and disrupts cell function, ultimately leading to cell death. This is particularly effective against rapidly dividing cells like lymphocytes, which are immune system cells targeted in these diseases.

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Payment

Payment terms 30 days net
We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Giovannoni, G. (2017). Cladribine to treat relapsing forms of multiple sclerosis. Neurotherapeutics, 14(4), 874-887.
Spurgeon, S., Yu, M., Phillips, J. D., & Epner, E. M. (2009). Cladribine: not just another purine analogue?. Expert opinion on investigational drugs, 18(8), 1169-1181.