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Alaptide – CAS 90058-29-0

Alaptide – CAS 90058-29-0 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)
95%+

Package contents
Alaptide

This compound is for research use only. We do not sell to patients.

Amount

5 g	€ 800	Stock
25 g	€ 2000	Stock
Do you want custom amount?			Custom amount

Amount

5 g

€ 800

Stock

25 g

€ 2000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 90058-29-0

IUPAC name: (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione

Other names: Alaptide, VUFB-15754, Cyclo(alanine-(1-amino-1-cyclopentane)carbonyl)

Molecular weight: 182.22 g/mol

Molecular formula: C₉H₁₄N₂O₂

InChI: InChI=1S/C9H14N2O2/c1-6-7(12)11-9(8(13)10-6)4-2-3-5-9/h6H,2-5H2,1H3,(H,10,13)(H,11,12)/t6-/m0/s1

Description

Alaptide is composed of two amino acids, L-alanine and cycloleucine, that are interlocked into a spirocycle.

Alaptide enables a significant stimulating effect of human diploid cells (LEP-19) without transformation changes in their morphology. This effect can be used in various areas of regenerative medicine, such as treating burn injuries, skin treatment etc.

Epidermal regeneration abilities were also proved on a number of tests using domestic pigs. It was found out that Alaptide causes a faster skin regeneration of various injuries.

Moreover, Alaptide is also used as a modifier of permeation through the stratum corneum (SC), the least permeable layer of skin. Even though it is almost insoluble in water (0.1104 g/100 mL), they are physical ways (such as milling with various emulsifiers and stabilisers) how to increase its solubility and, therefore, the ability of permeation.

Interestingly, it was originally developed and tested for its nootropic effects with possible oral administration.

You can read more in our article.

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Payment

Payment terms 30 days net
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References

CS Pat. 276270, 1992
CS Pat. 308845, 2021
Kasafirek et. al., Synthesis and Antiproliferative Activity of Spirocyclic Cyclodipeptides, Derivatives of 1-Amino-1-cyclobutanecarboxylic Acid, Collect. Czech. Chem. Commun. 1993, 58, 2987-2993. doi.org/10.1135/cccc19932987
Jampílek J., Dohnal J. (2015) Alaptide as Transdermal Permeation Modifier. In: Dragicevic N., Maibach H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_8
Nikifor Asatiani, Vít Novotný, David Lukáš, Petr Mikeš, A novel approach to studying the kinetics of release of Alaptide from Poly-ε-caprolactone nanofibers, Drug Deliv Sci Technol. 2021, 63, 102492. https://doi.org/10.1016/j.jddst.2021.102492.