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7-Methylguanosine – CAS 20244-86-4

7-Methylguanosine – CAS 20244-86-4 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

7-Methylguanosine

This compound is for research use only. We do not sell to patients.

Amount

1 g	€ 250	Stock
5 g	€ 1000	Stock
Do you want custom amount?			Custom amount

Amount

1 g

€ 250

Stock

5 g

€ 1000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 20244-86-4

IUPAC name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-1H-purin-9-ium-6-one

Other names: MG7, N7-Methylguanosine, M7G

Molecular weight: 297.27 g/mol

Molecular formula: C₁₁H₁₆N₅O₅⁺

InChI: InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1

Description

7-Methylguanosine (m7G) is a purine nucleoside that has been modified. It is a methylated form of guanosine that, when found in human urine, may be a biomarker for certain cancers. 7-methylguanosine has been used in RNAs to study and examine the reaction evolving methylguanosine. It also acts as a blocking group at the 5′ end of mRNA.

The 7-Methylguanosine structure is also known as a cap. It is found at the 5′ end of cytoplasmic mRNA.

RNA capping is a critical step in the production of a stable mature mRNA capable of translation, and it is involved in many functional processes.

The Cap-Binding-Complex (CBC) binds exclusively to m₇G-capped mRNA and is responsible for exporting it from the nucleus to the cytoplasm. Other translation factors are used in its place to be recognized by ribosomes. Thus, protein biosynthesis cannot begin without RNA capping. Furthermore, RNA capping serves as an identification group for recruiting protein factors for a variety of other critical cellular processes, such as pre-mRNA splicing, polyadenylation, and intracellular transport.

You can read more about RNA caps on our blog.

7-Methylguanosine has been used to remove residual phosphates from prerigor solution, the phosphate mop system, and the phosphorous standard solution.

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Payment

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References

Tomikawa, C. (2018). 7-Methylguanosine modifications in transfer RNA (tRNA). International journal of molecular sciences, 19(12), 4080.
Muthukrishnan, S., Both, G. W., Furuichi, Y., & Shatkin, A. J. (1975). 5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation. Nature, 255(5503), 33-37.
Alexandrov, A., Martzen, M. R., & Phizicky, E. M. (2002). Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. Rna, 8(10), 1253-1266.