7-iodo-7-deaza-2′-deoxyadenosine – CAS 166247-63-8
7-iodo-7-deaza-2′-deoxyadenosine – CAS 166247-63-8 is synthesised by Sigut Labs (Prague, Czech Republic).
Purity (LC-MS)
95%+
Package contents
7-iodo-7-deaza-2′-deoxyadenosine
This compound is for research use only. We do not sell to patients.
1 g | € 400 | Stock | ||
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Characterisation
Description
7-iodo-7-deaza-2′-deoxyadenosine is a synthetic nucleotide analogue that is used as a probe for mapping RNA sequences and as an inhibitor of bacterial growth. This compound is also used in the synthesis of oligodeoxynucleotides because it has a high affinity for guanine residues, which can be incorporated into the oligonucleotide chain by chemical ligation. The octameric form of 7-deaza-2′-deoxyadenosine is most active against bacterial cells.
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References
- Seela, F., Feiling, E., Gross, J., Hillenkamp, F., Ramzaeva, N., Rosemeyer, H., & Zulauf, M. (2001). Fluorescent DNA: the development of 7-deazapurine nucleoside triphosphates applicable for sequencing at the single molecule level. Journal of Biotechnology, 86(3), 269-279.
- Vrábel, M., Pohl, R., Votruba, I., Sajadi, M., Kovalenko, S. A., Ernsting, N. P., & Hocek, M. (2008). Synthesis and photophysical properties of 7-deaza-2′-deoxyadenosines bearing bipyridine ligands and their Ru (II)-complexes in position 7. Organic & Biomolecular Chemistry, 6(16), 2852-2860.
- Čapek, P., Cahová, H., Pohl, R., Hocek, M., Gloeckner, C., & Marx, A. (2007). An efficient method for the construction of functionalized DNA bearing amino acid groups through cross‐coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry–A European Journal, 13(21), 6196-6203.
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