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5-Iodo-2′-deoxyuridine triphosphate – CAS 3731-55-3

5-Iodo-2′-deoxyuridine triphosphate – CAS 3731-55-3 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

95%+

Package contents

5-Iodo-2′-deoxyuridine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 400	Stock
5 mg	€ 1200	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 400

Stock

5 mg

€ 1200

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 3731-55-3; 478843-67-3 (Et3NH+); 73431-55-7 (Na+)

IUPAC name: [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-iodo-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

Other names: dIUTP; 5-Iodo-2′-deoxyuridine triphosphate

Molecular weight: 594.04 g/mol

Molecular formula: C₉H₁₄IN₂O₁₄P₃

InChI: InChI=1S/C9H14IN2O14P3/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h2,5-7,13H,1,3H2,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1

Description

5-Iodo-2′-deoxyuridine triphosphate is a metabolite of 5-Iodo-2′-deoxyuridine that prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties. 5-Iodo-2′-deoxyuridine, used in topical applications, is effective against epithelial infections.

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Payment

Payment terms 30 days net
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References

Benson III, A. B., Trump, D. L., Cummings, K. B., & Fischer, P. H. (1985). Modulation of 5-iodo-2′-deoxyuridine metabolism and cytotoxicity in human bladder cancer cells by fluoropyrimidines. Biochemical pharmacology, 34(21), 3925-3931.
Fischer, P. H., Chen, M. S., & Prusoff, W. H. (1980). The incorporation of 5-iodo-5′-amino-2′, 5′-dideoxyuridine and 5-iodo-2′-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure. Biochimica et Biophysica Acta (BBA)-Nucleic Acids and Protein Synthesis, 606(2), 236-245.
Prusoff, W. H., & Chang, P. K. (1968). 5-Iodo-2 ‘-deoxyuridine 5 ‘-Triphosphate, an Allosteric Inhibitor of Deoxycytidylate Deaminase. Journal of Biological Chemistry, 243(2), 223-230.