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5-Hydroxymethyl-2′-deoxyuridine triphosphate – CAS 14167-70-5

5-Hydroxymethyl-2′-deoxyuridine triphosphate – CAS 14167-70-5 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

5-Hydroxymethyl-2′-deoxyuridine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 1450	Stock
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Amount

1 mg

€ 1450

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 14167-70-5, 2195353-80-9 (Na+)

IUPAC name: [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-[5-(hydroxymethyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

Other names: 5-Hydroxymethyl-dUTP; Hydroxymethyldeoxyuridine triphosphate

Molecular weight: 498.17 g/mol

Molecular formula: C₁₀H₁₇N₂O₁₅P₃

InChI: InChI=1S/C10H17N2O15P3/c13-3-5-2-12(10(16)11-9(5)15)8-1-6(14)7(25-8)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,6-8,13-14H,1,3-4H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t6-,7+,8+/m0/s1

Description

5-Hydroxymethyl-2′-deoxyuridine triphosphate is an important compound in DNA labeling and sequencing efforts. It functions as a modified nucleotide triphosphate and has the ability to assimilate within DNA during the polymerization process, making it easier to detect DNA changes. This useful chemical plays an important role in the comprehensive study of epigenetic changes and the effects of oxidative stress on DNA replication and repair pathways.

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Payment

Payment terms 30 days net
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References

Litosh, V. A., Wu, W., Stupi, B. P., Wang, J., Morris, S. E., Hersh, M. N., & Metzker, M. L. (2011). Improved nucleotide selectivity and termination of 3′-OH unblocked reversible terminators by molecular tuning of 2-nitrobenzyl alkylated HOMedU triphosphates. Nucleic acids research, 39(6), e39-e39.
Evans, M. D., Saparbaev, M., & Cooke, M. S. (2010). DNA repair and the origins of urinary oxidized 2′-deoxyribonucleosides. Mutagenesis, 25(5), 433-442.