Home → E-shop → Nucleotides → 3′,4′-Didehydro-3′-deoxycytidine monophosphate – CAS 2499590-47-3

3′,4′-Didehydro-3′-deoxycytidine monophosphate – CAS 2499590-47-3

3′,4′-Didehydro-3′-deoxycytidine monophosphate – CAS 2499590-47-3 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxycytidine monophosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 1500	Stock
5 mg	€ 3000	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 1500

Stock

5 mg

€ 3000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 2499590-47-3, 2657712-09-7 (Na+ salt)

IUPAC name: 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-4-Amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]-1,2-dihydropyrimidin-2-one monophosphate

Other names: 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-2(1H)-Pyrimidinone monophosphate, DdhCMP, DdhC-MP

Molecular weight: 305.18 g/mol

Molecular formula: C₉H₁₂N₃O₇P

InChI: InChI=1S/C9H12N3O7P/c10-7-1-2-12(9(14)11-7)8-6(13)3-5(19-8)4-18-20(15,16)17/h1-3,6,8,13H,4H2,(H2,10,11,14)(H2,15,16,17)/t6-,8-/m1/s1

Description

3′,4′-didehydro-3′-deoxycytidine monophosphate is a metabolite of 3′,4′-didehydro-3′-deoxycytidine triphosphate that has been proven to have an antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

3′,4′-didehydro-3′-deoxycytidine monophosphate is provided as triethylammonium salt.

Chemicals are distributed worldwide

Buy 3′,4′-Didehydro-3′-deoxycytidine monophosphate now, and get your order in 48 hours

Shipping through DHL in 48 hours
All compounds are safely and rigorously packed

Payment

We are sending the invoice the same day as the shipment
We are able to modify the invoice for the academic institution, so the order can be paid from grants

References

Wang, F. (2007). Unsaturated Didehydrodeoxycytidine Drugs. 1. Impact of CC Positions in the Sugar Ring. The Journal of Physical Chemistry B, 111(32), 9628-9633.
Torrance, C. J., Agrawal, V., Vogelstein, B., & Kinzler, K. W. (2001). Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nature biotechnology, 19(10), 940-945.
Mehta, R., Chekmeneva, E., Jackson, H., Sands, C., Mills, E., Arancon, D., … & Sriskandan, S. (2022). Antiviral metabolite 3′-deoxy-3′, 4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med, 3(3), 204-215.
McGall, G. H., Stubbe, J., & Kozarich, J. W. (1991). Acyl migration in the production of thymine. Propenal from 3′-O-benzoyl-5′-deoxy-4′-(hydroperoxy) thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation. The Journal of Organic Chemistry, 56(1), 48-55.
Bernheim, A., Millman, A., Ofir, G., Meitav, G., Avraham, C., Shomar, H., … & Sorek, R. (2021). Prokaryotic viperins produce diverse antiviral molecules. Nature, 589(7840), 120-124.