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3′,4′-Didehydro-3′-deoxyadenosine diphosphate– CAS 2761971-64-4

3′,4′-Didehydro-3′-deoxyadenosine diphosphate– CAS 2761971-64-4 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxyadenosine diphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg	€ 3200	Stock
5 mg	€ 6000	Stock
Do you want custom amount?			Custom amount

Amount

1 mg

€ 3200

Stock

5 mg

€ 6000

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 2761971-64-4

IUPAC name: ((4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl trihydrogen diphosphate

Other names: DdhA-DP, Ddh-A-DP, 3′,4′-Didehydro-3′-deoxyadenosine diphosphate, DdhA diphosphate

Molecular weight: 409.19 g/mol

Molecular formula: C₁₀H₁₃N₅O₉P₂

InChI: InChI=1S/C10H13N5O9P2/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(23-10)2-22-26(20,21)24-25(17,18)19/h1,3-4,6,10,16H,2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/t6-,10+/m0/s1

Description

3′,4′-Didehydro-3′-deoxyadenosine diphosphate is a metabolite of is 3′,4′-Didehydro-3′-deoxyadenosine (DdhA). A related compound, 3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

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Payment

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References

Magnusson, O. T., & Frey, P. A. (2000). Synthesis and Characterization of 3 ‘, 4 ‘-Anhydroadenosylcobalamin: A Coenzyme B12 Analogue with Unusual Properties. Journal of the American Chemical Society, 122(37), 8807-8813.
Petrová, M., Buděšínský, M., & Rosenberg, I. (2010). Straightforward synthesis of 3′-deoxy-3′, 4′-didehydronucleoside-5′-aldehydes via 2′, 3′-O-orthoester group elimination: a simple route to 3′, 4′-didehydronucleosides. Tetrahedron Letters, 51(52), 6874-6876.