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3′,4′-Didehydro-3′-deoxyguanosine – CAS 1262202-31-2

3′,4′-Didehydro-3′-deoxyguanosine – CAS 1262202-31-2 is synthesized by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxyguanosine

This compound is for research use only. We do not sell to patients.

Amount

10 mg	€ 400	Stock
100 mg	€ 1500	Stock
500 mg	€ 3000	Stock
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Amount

10 mg

€ 400

Stock

100 mg

€ 1500

Stock

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Characterisation

CAS: 1262202-31-2

IUPAC name: 3′,4′-Didehydro-3′-deoxyguanosine

Other names: DdhG, Ddh-G, 2-amino-9-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-1,9-dihydro-6H-Purin-6-one

Molecular weight: 265.23 g/mol

Molecular formula: C₁₀H₁₁N₅O₄

InChI: InChI=1S/C10H11N5O4/c11-10-13-7-6(8(18)14-10)12-3-15(7)9-5(17)1-4(2-16)19-9/h1,3,5,9,16-17H,2H2,(H3,11,13,14,18)/t5-,9-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyguanosine is an analogue of guanosine. A related compound, 3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

This product was developed as part of the European Union-funded grant program Czech Rise Up 3.0 – Výzkum medicínských řešení v době digitalizace.

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Payment

Payment terms 30 days net
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References

WO2022038539 A2 2022-02-24
Petrová, M., Buděšínský, M., & Rosenberg, I. (2010). Straightforward synthesis of 3′-deoxy-3′, 4′-didehydronucleoside-5′-aldehydes via 2′, 3′-O-orthoester group elimination: a simple route to 3′, 4′-didehydronucleosides. Tetrahedron Letters, 51(52), 6874-6876.