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2′-Azido-2′-deoxyuridine triphosphate – CAS 106448-30-0

2′-Azido-2′-deoxyuridine triphosphate – CAS 106448-30-0 is synthesised by Sigut Labs (Prague, Czech Republic).

Purity (LC-MS)

97%+

Package contents

2′-Azido-2′-deoxyuridine triphosphate Et₃NH⁺salt

This compound is for research use only. We do not sell to patients.

Amount

1 mg		€ 2800	Stock
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Amount

1 mg

€ 2800

Stock

Do you want custom amount?

Custom amount

Characterisation

CAS: 106448-30-0, 1383937-01-6 (Na+)

IUPAC name: ((2R,3S,4R,5R)-4-azido-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Other names: N3-dU; N3dUrd

Molecular weight: 509.15 g/mol

Molecular formula: C₉H₁₄N₅O₁₄P₃

InChI: InChI=1S/C9H14N5O14P3/c10-13-12-6-7(16)4(26-8(6)14-2-1-5(15)11-9(14)17)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,4,6-8,16H,3H2,(H,21,22)(H,23,24)(H,11,15,17)(H2,18,19,20)/t4-,6-,7-,8?/m1/s1

Description

The nucleotide analog 2′-Azido-2′-deoxyuridine-5′-triphosphate acts as an allosteric inhibitor of numerous DNA polymerases, inhibiting cell proliferation. 2′-Azido-2′-deoxyuridine-5′-triphosphate binds to ATP’s phosphate group, inhibiting protein synthesis. In specifically, it inhibits the polymerase activity of herpes simplex virus type 1 by binding to the enzyme’s active site, blocking viral replication. 2′-Azido-2′-deoxyuridine-5′-triphosphate also binds to cytosolic Ca2+ and activates Ca2+ signaling pathways, which causes cell death.

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