Remdesivir – CAS 1809249-37-3

Description

Remdesivir (also known as GS-5734) is synthesised by Sigut Labs (Prague, Czech Republic). It is an antiviral drug that belongs to the class of nucleotide analogues. It was mainly developed as a treatment for filovirus infections such as Ebola virus disease or Marburg virus. Subsequently, Remdesivir was found to show antiviral activity against other single-stranded RNA viruses such as respiratory syncytial virus, Nipah virus, Hendra virus, Junin virus, Lassa fever virus and the coronaviruses (including MERS and SARS viruses). Recently it is being studied as a promising medication for the treatment of COVID-19 (new SARS type virus).

Remdesivir, developed by Gilead Sciences, is an adenosine prodrug that metabolizes into its active form GS-441524 which interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production.

We are also offering active metabolites of Remdesivir: Remdesivir triphosphate, diphosphate or monophosphate.

Chemicals are distributed worldwide

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Payment

• Payment terms 30 days net
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References

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• Ju, J.; Li, X.; Kumar, S.; Jockusch, S.; Chien, M.; Tao, C.; Morozova, I.; Kalachikov, S.; Kirchdoerfer, R. N.; Russo, J. J., Nucleotide analogues as inhibitors of SARS-CoV polymerase. bioRxiv 2020, 1-18.
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